Scientific Name: Manis javanica
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Pholidota-> Manidae-> Manis
Summary: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008] [NCBI] [Proteinatlas]
Data set information
| Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
|---|---|---|---|---|---|---|
| Vthunter_0035 | 2021.04 | 10X Genomics | Duodenum | Normal | 1482 | Link |
| Vthunter_0036 | 2021.04 | 10X Genomics | Esophagus | Normal | 24581 | Link |
| Vthunter_0037 | 2021.04 | 10X Genomics | Heart | Normal | 12958 | Link |
| Vthunter_0038 | 2021.04 | 10X Genomics | Kidney | Normal | 4481 | Link |
| Vthunter_0039 | 2021.04 | 10X Genomics | LargeIntestine | Normal | 3328 | Link |
| Vthunter_0040 | 2021.04 | 10X Genomics | Liver | Normal | 5694 | Link |
| Vthunter_0041 | 2021.04 | 10X Genomics | Lung | Normal | 13720 | Link |
| Vthunter_0042 | 2021.04 | 10X Genomics | Spleen | Normal | 3207 | Link |
| Vthunter_0043 | 2021.04 | 10X Genomics | Stomach | Normal | 12485 | Link |
Featureplot of receptors
Expression: Ubiquitous expression in skin (RPKM 9.8), esophagus (RPKM 9.6) and 23 other tissues
